Women in Transplantation Research Grant for Projects on Gender and Sex in Transplantation (LMIC)

Overview

Women in Transplantation will provide funding to an investigator to support research on issues of sex and gender in solid organ transplantation and immunology. The spectrum of studies includes basic, clinical and translational. The recipient must be a clinician and/or clinical and/or basic science researcher in a low or lower-middle income country as defined by the OECD. The applicant must identify a research mentor from within the WIT membership who has a track record of expertise in transplantation and/or immunology research and who demonstrates a willingness and ability to support the applicant in the conduct of the research.

General Information
  1. The grant provides one research grant for two years at a maximum of $15,000 per year. Research must commence on July 1st 2024 and conclude on June 30th 2026.
  2. The research start date cannot be deferred for any reason.
  3. Applications must be submitted in full by April 1st 2024 in order to be reviewed.
  4. The recipient will sign a letter of agreement with WIT. Payments will be issued to the recipient’s institution by WIT, and the recipient will report to the WIT Pillar 2.
Research Focus
The 2024 Women in Transplantation Research Grant for Projects on Sex and Gender in Transplantation (LMIC) will fund research that contributes to our understanding of the impact of sex and/or gender in transplantation. Such work includes, but is not limited to: studies of the impact of sex on transplant outcomes, sex differences in the immune response in organ transplantation, the influence of sex hormones on inflammatory responses, sex differences in the pharmacokinetics and pharmacodynamics of immunosuppressive medications, disparities in access to transplantation based on gender or sex, the complex challenge of HLA sensitization in women following pregnancy, and the influence of gender on organ donation. Epidemiologic, clinical, translational, and basic, studies are all necessary and will be considered.
Eligibility
  1. The Applicant
    1. The applicant (MD, PhD, PharmD, or equivalent degree) must work in the field of transplantation.
    2. The minimum protected research time is 30%
  2. Applicant’s Sponsor and Institutional Support
    1. The applicant must have a sponsor/mentor who is a WIT member with research expertise in transplantation or immunology relevant to the proposed project and who articulates clear willingness and ability to support the applicant.
    2. The applicant’s Department Chair or equivalent supervisor must provide a letter of support indicating that the applicant has the required protected time, space, and resources to carry out the proposed project.
    3. Women in Transplantation membership: The applicant’s mentor must be an active member of both Women in Transplantation and TTS or have submitted a completed membership application deadline. Applicants are strongly encouraged to choose a mentor from among WIT members who have volunteered to provide LMIC grant mentorship.
  3. Previous Funding/Funding from Other Sources
    1. The applicant may be a past or current recipient of other foundation fellowship research grants.
    2. The applicant may currently hold career development awards, or a mentored scientist award.
    3. If the applicant is currently receiving funding for a project similar to the topics described in this RFA, the applicant should explain how the funds of the Women in Transplantation grant would not overlap with the funds of the other research support.
  4. Miscellaneous
    1. Citizenship: There is no restriction on citizenship.
    2. Laboratory: there is no restriction on laboratory location/country
Specific Application Requirements

Applications that do not conform to these guidelines will be returned without review.

  1. Name, title, and institution of principle investigator, co-investigator, and/or key co- collaborator(s)
  2. Abstract of the proposed research plan: This document should concisely summarize the project in 400 words or less. The abstract should introduce the project and note its relevance to transplantation. It should describe the long-term objectives and specific aims, research design, and methods for achieving these goals.
  3. Applicant’s biosketch (maximum-5 pages, 12 font, Times News Roman, single space, 2x2 cm margin) to include all usual and pertinent information, particularly describing other past and current research funding and prior published work.
  4. The biosketch of the mentor.
  5. Complete proposed research plan: This document is limited to five pages (12-font, Times News Roman, single space, 2x2 cm margin); the page limit does not include references. The following sections must be included:
    1. Aims: include the key questions posed or hypotheses to be tested
    2. Introduction: provide the rationale for the research
    3. Preliminary Results (if any): show preliminary results supporting the research plan
    4. Research Plan: explain how the questions or hypothesis will be studied, with emphasis on experimental design over the details of the specific methods to be used. Anticipated results and potential pitfalls and alternative approaches should be briefly discussed. Specific research (and, if applicable, training) goals to be reached at the end of the grant should also be provided.
    5. The research plan should include a description of relevant facilities/capabilities
  6. Mentor narrative: should not exceed three pages and should include:
    1. A description of the support they will provide to the applicant to ensure success of the proposed project.
    2. A description of the mentor's background in research and mentorship.
    3. The role of the applicant in the project.
    4. A description of the role of the applicant in preparing the application. The applicant is expected to take the lead in writing the application, but input from the mentor is expected.
    5. An explanation of any mitigating or additional factors that need to be considered in terms of eligibility (e.g. account of extra years or a change in research field).
  7. Budget
    1. The grant may be used to provide salary support for the researcher and/or supplies/materials or other costs related to the conduct of the research (including salaries for research assistants). Costs related to travel to the mentor’s lab may be permitted but must be justified. No costs for institutional overhead are permitted.
    2. A detailed budget, with justification of each item must be included.
Review Process and Notification
  1. Proposals are due by April 1st 2024.
  2. Funding decisions will be made by an expert review committee from the WIT peer members. Grants will be scored based on novelty, research approach, feasibility of obtaining relevant data, and engagement of the mentor.
  3. All applicants will be notified of their application status in May 2024 (one month post submission)
  4. For the selected individuals, the term of the grant will begin July 1st 2024. (three months post submission).
Support

It is envisaged that the Grant Recipient payment of $30,000 USD will be paid in 2 payments of $15,000.00 USD per year across a 2 year period, upon receipt of the invoice or on another convenient date agreed upon by both parties, and receipt of signed agreement.

  1. The first payment is due on or before July 1st 2024
  2. The second payment is due on July 1st 2025.

Payments shall be wired to the Grant Recipient using the coordinates provided on the invoice.